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The US had obtained four million cinchona seeds from the Philippines and began operating cinchona plantations in Costa Rica. Additionally, they began harvesting wild cinchona bark during the Cinchona Missions. Such supplies came too late. Bromo Quinine were brand name cold tablets containing quinine, manufactured by Grove Laboratories. They were first marketed in and available until at least the s. The bark of Remijia contains 0. The bark is cheaper than bark of Cinchona.

As it has an intense taste, it is used for making tonic water. From , to , the US Food and Drug Administration FDA received reports of health problems related to quinine use, including 23 which had resulted in death. Pfizer Pharmaceuticals had been selling the brand name Legatrin for this purpose.

Doctors may still prescribe quinine, but the FDA has ordered firms to stop marketing unapproved drug products containing quinine. The FDA is also cautioning consumers about off-label use of quinine to treat leg cramps. Because malaria is life-threatening, the risks associated with quinine use are considered acceptable when used to treat that affliction.

It is marketed as a treatment for malaria and is sold in the United States only by prescription.

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Quinine is sometimes detected as a cutting agent in street drugs such as cocaine and heroin. Quinine is used as a treatment for Cryptocaryon irritans commonly referred to as white spot, crypto or marine ich infection of marine aquarium fish. From Wikipedia, the free encyclopedia. Not to be confused with quinidine , quinone , or quinoline.

IUPAC name. Interactive image. Main article: quinine total synthesis. See also: History of malaria. Medscape Reference. Archived from the original on 2 February Retrieved 29 January Archived from the original on 5 December Retrieved 2 November The Cochrane Database of Systematic Reviews. Chemistry: The Molecular Science. Archived from the original on 15 September Traditional Medicinal Plants and Malaria.

CRC Press. Hoboken, N. Archived from the original on 4 March World Health Organization model list of essential medicines: 21st list Geneva: World Health Organization.

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International Drug Price Indicator Guide. Retrieved 12 January World Health Organization. Archived from the original PDF on 5 August Retrieved 10 August Archived from the original on 19 February Retrieved 21 February Archived from the original on 22 October Retrieved 19 January Consumer Reports. Retrieved 20 January British Journal of Clinical Pharmacology.

Recommendations and Reports. The New England Journal of Medicine. USA: Sourcebooks, Inc. Retrieved 8 June September Molecular Pharmacology. Food and Drug Administration. Department of Health and Human Services.

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Retrieved 9 October Official Journal of the European Union. Springer Chapter 2. American Journal of Hematology. April Archived PDF from the original on 20 January Archived from the original on 6 February International Journal for Parasitology. Retrieved 28 January Archived from the original on 13 September J Am Chem Soc.

Angewandte Chemie International Edition in German. European Journal of Biochemistry.

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Natural Product Reports. London: Laurence King. David C. Archived 8 May at the Wayback Machine From p.

Este arbol tiene una corteza gruessa, muy solida y dura, que en esto y en el color parece mucho a la corteza del palo que llaman Guayacan: en la superfiecie tiene una pelicula delgada blanquisca, quebrada por toda ella: tiene la corteza mas de un dedo de gruesso, solida, y pesada: la qual gustada tiene notable amargor, como el dela Genciana: tiene en el gusto notable astriction, con alguna aromaticidad, porque al fin del mascar la respira della buen olor. Tienen los Indios esta corteza en mucho, y usan de lla en todo genero de camaras, que sean con sangre, o sin ella. The Indians hold this bark in high regard, and use it for all sorts of diarrhea, that are with blood [i.

The Spanish [who are] tired of this disease, on the advice of the Indians, have used this bark and have healed many of those with it. They take as much as a small bean, make [it into] powder, take it in red wine or in appropriate water, if they have fever or illness: it must be taken in the morning on an empty stomach, three or four times: otherwise, using the order and regimen that suits those who have diarrhea.

Archived 5 May at the Wayback Machine From p. Tiene dos cortezas, la una gruessa muy solida dura, que assi en la sustancia como en el color es muy semejante al Guayacan: la otra es mas delgada y blaquezina, la qual es amarga con alguna estipticidad: y de mas desto es aromatica.

Tienen la en mucho nuestros Indios, porque la usan contra qualesquier camaras, tomando de poluo peso de uno drama o poco mas, desatado en agua azerada, o vino tinto. It has two barks, one [is] thick, very solid, [and] hard, which in substance as well as in color is much like guayacan [i. Our Indians regard it highly, because they use it against any diarrheas, taking a weight of a dram or a bit more of the powder, mixing it in mineral water, or red wine. Malaria Journal. New Scientist. Of the Society of Jesus i. Archived 22 May at the Wayback Machine From p. Hernando de Leon Garavito, llevando gran cantidad de la corteza de la quina, cuyo conocimiento extendieron por el mundo los jesuitas.

After almost 20 days of sailing, medicine arrived in the city of Panama, where it was transloaded onto mules. It then traveled the malarial isthmus as far as Portobelo, thence to Cartagena [in Colombia] and Havana. Quinine: malaria and the quest for a cure that changed the world.

New York, NY: Perennial. Quinine and Quarantine. De Jussieu accompanied de la Condamine on the latter's expedition to Peru. Annales de Chimie et de Physique in French.

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