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Although chloroquine is an antimalarial, it is often not sufficient for prophylaxis.


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Chloroquine used to be the antimalarial of choice and it was widely used for from onwards. As a result, the malaria parasites endemic to certain regions developed a resistance to chloroquine.

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Resistance to chloroquine was observed as early as the s. Whether chloroquine and proguanil tablets will keep you safe during your trip depends on where you are going.


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You will need to use a newer antimalarial such as Malarone instead. You cannot take it if you are allergic to any of the ingredients or if you are currently taking a medication called amiodarone which is used to control your heart rate.

If you are currently taking any other medication it is also important that you ask a doctor or pharmacist whether you can combine it with chloroquine and proguanil. The same applies if you are pregnant, trying for a baby or breastfeeding. However, it is important that you make sure that it will protect you from the malaria parasites endemic to the region you are travelling to. The dose of chloroquine and proguanil depends on your body weight. The standard dose for adults over 45kg is two tablets mg base of chloroquine and 2 tablets mg of proguanil. If you are unsure, speak to a nurse or pharmacist who will be able to advise on the correct dose for you.

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Start taking chloroquine one week before entering the malaria risk area. For proguanil it is sufficient to start taking the tablets 2 days before entering the risk area.


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You need to take the prescribed dose of chloroquine once every week on the same day; proguanil should be taken once every day. You should take the tablets after a meal and swallow them whole with water.

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For young children or those who cannot swallow, the tablets can be crushed and added to milk, honey or jam. For a full list of all risk and side effects associated with chloroquine and proguanil read the patient information leaflet. Travel Vaccinations. During your appointment, the nurse or pharmacist will assess which vaccines or medications you need.

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Every year I go to Africa and nearby islands at least twice and every time I have to think about my health before I go. Usually I take Chloroquine and it helps me keep away from malaria which is very common in Africa.