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This patent prevents other companies from copying the drug during that time so they can earn back their Research and Development costs through being the exclusive supplier of the product. After the patent expires however, other companies can develop a "generic" version of the product.

These versions generally are offered at much lower prices because the companies do not have the same development costs as the original company who developed the medication. The main thing to realize here though is that the two products are therapeutically comparable. They may look different, and be called something different, but they are required to be have the same active ingredient.

The two most generally accepted methods to prove the safety of a generic version of a drug are to either repeat most of the chemistry, animal and human studies originally done, or to show that the drug performs comparably with the original brand name drug.

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This second option is called a "comparative bioavailability" study. During this type of study, volunteers are given the original drug, and then separately later the generic drug. The rates at which the drug is delivered to the patient into their blood stream or otherwise absorbed are measured to ensure they are the same. Because the same active ingredient is used the major concern is just that it delivers the common chemical s at the same rate so that they have the same effect.

Please note that the methods that the manufacturers use may vary from country to country. Home Browse medications Z Zithromax. Zithromax mg.

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Zithromax (Azithromycin)

Full information about Zithromax. Basic Information On Zithromax Zithromax is used in the treatment of patients with bacterial infections. Zithromax Dosage For treatment of sexually transmitted infections, the dose is mg administered once. Azithromycin was not implicated in clinical trials with drug interactions with fosphenytoin. However, specific drug interaction studies have not been performed with the combination of azithromycin and fosphenytoin. Gemifloxacin: Moderate Gemifloxacin should be used cautiously with other agents that may prolong the QT interval or increase the risk of torsades de pointes TdP such as azithromycin.

QT prolongation and torsades de pointes have been spontaneously reported during azithromycin postmarketing surveillance. Gemifloxacin may also prolong the QT interval in some patients. The maximal change in the QTc interval occurs approximately 5 to 10 hours following oral administration of gemifloxacin. The likelihood of QTc prolongation may increase with increasing dose of the drug; therefore, the recommended dose should not be exceeded especially in patients with renal or hepatic impairment where the Cmax and AUC are slightly higher.

Gemtuzumab Ozogamicin: Moderate Use gemtuzumab ozogamicin and azithromycin together with caution due to the potential for additive QT interval prolongation and risk of torsade de pointes TdP. If these agents are used together, obtain an ECG and serum electrolytes prior to the start of gemtuzumab and as needed during treatment.

Although QT interval prolongation has not been reported with gemtuzumab, it has been reported with other drugs that contain calicheamicin.

How should this medicine be used?

Gilteritinib: Moderate Use caution and monitor for evidence of QT prolongation if concurrent use of gilteritinib and azithromycin is necessary. Gilteritinib has been associated with QT prolongation. Glasdegib: Major Avoid coadministration of glasdegib with azithromycin due to the potential for additive QT prolongation.

If coadministration cannot be avoided, monitor patients for increased risk of QT prolongation with increased frequency of ECG monitoring. Glasdegib therapy may result in QT prolongation and ventricular arrhythmias including ventricular fibrillation and ventricular tachycardia. Glycopyrrolate; Formoterol: Moderate Due to a possible risk for QT prolongation and torsade de pointes TdP , azithromycin and long-acting beta-agonists should be used together cautiously.

Goserelin: Moderate Consider whether the benefits of androgen deprivation therapy i. Granisetron: Moderate Use granisetron with caution in combination with azithromycin due to the risk of QT prolongation. Granisetron has been associated with QT prolongation. Halofantrine: Severe There have been case reports of QT prolongation and torsade de pointes TdP with the use of azithromycin in postmarketing reports.

Other drugs, such as halofantrine, have been specifically established to have a causal association with QT prolongation and TdP and are contraindicated for use with drugs that potentially cause QT prolongation, such as azithromycin.

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Halogenated Anesthetics: Major Halogenated Anesthetics should be used cautiously and with close monitoring with azithromycin. Haloperidol: Moderate Use caution when combining haloperidol concurrently with azithromycin. QT prolongation and torsade de pointes TdP have been observed during treatment with haloperidol and with azithromycin. Excessive doses particularly in the overdose setting or IV administration of haloperidol may be associated with a higher risk of QT prolongation.

Halothane: Major Halogenated Anesthetics should be used cautiously and with close monitoring with azithromycin. Histrelin: Moderate Consider whether the benefits of androgen deprivation therapy i. Hydroxychloroquine: Major Avoid coadministration of hydroxychloroquine and azithromycin. Hydroxychloroquine increases the QT interval and should not be administered with other drugs known to prolong the QT interval.

Ventricular arrhythmias and torsade de pointes TdP have been reported with the use of hydroxychloroquine. Hydroxyzine: Moderate Consider the risk of QT prolongation, which can be fatal, when administering azithromycin to patients on other QT prolonging agents such as hydroxyzine. Postmarketing data indicate that hydroxyzine causes QT prolongation and TdP. Ibutilide: Major Due to an increased risk for QT prolongation and torsade de pointes TdP , cautious use of ibutilide with azithromycin is advised.

Ibutilide administration can cause QT prolongation and TdP; proarrhythmic events should be anticipated. The potential for proarrhythmic events with ibutilide increases with the coadministration of other drugs that prolong the QT interval. Azithromycin has been associated with post-marketing reports of QT prolongation and TdP. Iloperidone: Major Concurrent use of iloperidone and azithromycin should be avoided due to an increased risk for QT prolongation and torsade de pointes TdP.

Iloperidone has been associated with QT prolongation, and cases of QT prolongation and TdP have been reported with the post-marketing use of azithromycin.

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Imipramine: Minor Due to a possible risk for QT prolongation and torsade de pointes TdP , azithromycin and tricyclic antidepressants TCAs should be used together cautiously. Indacaterol: Moderate Due to a possible risk for QT prolongation and torsade de pointes TdP , azithromycin and long-acting beta-agonists should be used together cautiously. Indacaterol; Glycopyrrolate: Moderate Due to a possible risk for QT prolongation and torsade de pointes TdP , azithromycin and long-acting beta-agonists should be used together cautiously.

Inotuzumab Ozogamicin: Major Avoid coadministration of inotuzumab ozogamicin with azithromycin due to the potential for additive QT interval prolongation and risk of torsade de pointes TdP. If coadministration is unavoidable, obtain an ECG and serum electrolytes prior to the start of treatment, after treatment initiation, and periodically during treatment. Inotuzumab has been associated with QT interval prolongation.

Isoflurane: Major Halogenated Anesthetics should be used cautiously and with close monitoring with azithromycin. Itraconazole: Moderate Use itraconazole with caution in combination with azithromycin. Itraconazole has been associated with prolongation of the QT interval. Ivosidenib: Major Avoid coadministration of ivosidenib with azithromycin due to an increased risk of QT prolongation.

If concomitant use is unavoidable, monitor ECGs for QTc prolongation and monitor electrolytes; correct any electrolyte abnormalities as clinically appropriate. An interruption of therapy and dose reduction of ivosidenib may be necessary if QT prolongation occurs. Prolongation of the QTc interval and ventricular arrhythmias have been reported in patients treated with ivosidenib.

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Ketoconazole: Moderate Use ketoconazole with caution in combination with azithromycin. Ketoconazole has been associated with prolongation of the QT interval. Lanthanum Carbonate: Major Oral compounds known to interact with antacids, like macrolides, should not be taken within 2 hours of dosing with lanthanum carbonate.