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Sexually transmitted and other reproductive tract infections: guide to essential practice. Occurrence of congenital syphilis after maternal treatment with azithromycin during pregnancy. Piperaquine: a resurgent antimalarial drug. Electrocardiographic safety evaluation of dihydroartemisinin piperaquine in the treatment of uncomplicated falciparum malaria. In vitro antimalarial activity of azithromycin, artesunate, and quinine in combination and correlation with clinical outcome. Antimicrob Agents Chemother. Assessment of azithromycin in combination with other antimalarial drugs against Plasmodium falciparum in vitro.

Azithromycin plus artesunate versus artemether-lumefantrine for treatment of uncomplicated malaria in tanzanian children: a randomized, controlled trial. Noedl H, Krudsood S, et al. Azithromycin combination therapy with artesunate or quinine for the treatment of uncomplicated Plasmodium falciparum malaria in adults: a randomized, phase 2 clinical trial in Thailand.

Azithromycin combination therapy for the treatment of uncomplicated falciparum malaria in Bangladesh: an open-label randomized, controlled clinical trial. Pfizer Labs.

French study finds anti-malarial and antibiotic combo could reduce COVID duration – TechCrunch

Zithromax Product Label. Single-dose azithromycin versus erythromycin or amoxicillin for Chlamydia trachomatis infection during pregnancy: a meta-analysis of randomised controlled trials. Int J Antimicrob Agents. Once weekly azithromycin therapy for prevention of Mycobacterium avium complex infection in patients with AIDS: a randomized, double-blind, placebo-controlled multicenter trial.

Azitliromycin-related ototoxicity in patients infected with human immunodeficiency virus. Malaria prophylaxis using azithromyca double-blind, placebo-controlled trial in Irian Jaya, Indonesia. Antimalarial agents in pregnancy. Pruritus and antimalarial drugs in Africans. Chloroquine is grossly overdosed and overused but well tolerated in Guinea-bissau. Jaeger A. Poisonous substances: quinine and chloroquine. Chemo prophylaxis and other protective measures: preventing pregnancy malaria.

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In: Duffy P, editor. Malaria in pregnancy: deadly parasite, susceptible host. London: Taylor and Francis; Most H. Clinical trials of antimalarial drugs. In: Coates JB, editor. Internal medicine in world war II.


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Office of the Surgeon General, Medical Department. Drugs used in parasitic diseases. WHO model prescribing information.

Efficacy and safety of chloroquine for treatment in patients with uncomplicated Plasmodium vivax infections in endemic countries. Baird JK. Resistance to therapies for infection by Plasmodium vivax. Clin Microbiol Rev.

French Scientists Report Successful Results from a COVID-19 Drug Combination

Guidelines for the treatment of malaria. New developments in Plasmodium vivax malaria: severe disease and the rise of chloroquine resistance. Curr Opin Infect Dis. Failure of combined chloroquine and high-dose primaquine therapy for Plasmodium vivax malaria acquired in Guyana, South America. Chehuan YM, etal. Chloroquine-resistant Plasmodium vivax, Brazilian Amazon. Emerg Infect Dis. Increase of birth weight following chloroquine chemoprophylaxis during the first pregnancy: results of a randomized trial in Cameroon.

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Results of a study in Benin. Comparison of the therapeutic efficacy of chloroquine and sulphadoxine-pyremethamine in children and pregnant women. Trop Med Int Health. Beyond chloroquine: implications of drug resistance for evaluating malaria therapy efficacy and treatment policy in Africa. A molecular marker for chloroquine-resistant falciparum malaria.

Reemergence of chloroquine-sensitive Plasmodium falciparum malaria after cessation of chloroquine use in Malawi. Return of chloroquine antimalarial efficacy in Malawi. Return of chloroquine-susceptible falciparum malaria in Malawi was a reexpansion of diverse susceptible parasites. The impact of antimalarial drug resistance mutations on parasite fitness, and its implications for the evolution of resistance.

Drug Resist Updat. Chloroquine resistant Plasmodium falciparum malaria in Guinea-Bissau. Chloroquine resistant P. Infect Genet Evol. Similar efficacy and tolerability of double-dose chloroquine and artemether-lumefantrine for treatment of Plasmodium falciparum infection in Guinea-Bissau: a randomized trial. PLoS Pathog. Azithromycin for treating uncomplicated malaria. Intermittent screening and treatment versus intermittent preventive treatment of malaria in pregnancy: a randomised controlled non-inferiority trial.

A phase 2, open-label, non-comparative trial of azithromycin 2G plus chloroquine mg base daily for three days for the treatment of uncomplicated plasmodium falciparum malaria. In vitro and in vivo uptake of azithromycin CP, by phagocytic cells: possible mechanism of delivery and release at sites of infection. In vitro efficacy, resistance selection, and structural modeling studies implicate the malarial parasite apicoplast as the target of azithromycin. J Biol Chem. Retsema J, Fu W. Macrolides: structures and microbial targets.

Schliinzen F, Harms JM, et al. Structural basis for the antibiotic activity of ketolides and azalides. Apicoplast translation, transcription and genome replication: targets for antimalarial antibiotics. Trends Parasitol.


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