Plaquenil vs chloroquine phosphate pills

An analysis by the Biotechnology Industry Organization says they worked out only That means that three-quarters of the time, medicines against infectious disease that looked promising in small studies either were ineffective or had side effects that made them unusable. It goes to one of the big truths about how doctors, eager to see a new drug succeed, can subconsciously lie to themselves with clinical studies: To be trustworthy, these studies often need to be randomized.

The use of randomization as the standard way to design a medical study goes back to another deadly infectious disease: tuberculosis. In the early part of the 20th century, it was a scourge, and many doctors turned to gold-based treatments, to try and control it. They turned out to be toxic and ineffective. That study, published in the British Medical Journal in , became the basis for most modern medical research. The study Trump and others have touted was anything but randomized.

Instead, Covid patients were treated with either hydroxychloroquine or the combination of hydroxychloroquine and azithromycin, an antibiotic also known as Zithromax, at a hospital in Marseille, France. But for doctors on the front lines, particularly in New York City, where hospitals are becoming overwhelmed and where there are many patients on ventilators, the drugs could be an immediate option. Perhaps as a result, there are shortages cropping up for patients with lupus and other diseases who need the drug.

Why Trump is at odds with his medical experts over Covid drugs - STAT

The University of California, San Francisco , and the University of Washington both recommend hydroxycholoroquine for very sick Covid patients. The qualms about the French study extend to two other studies of antiviral drugs as potential Covid treatments. A study of 80 patients given the Japanese flu drug favipriavir, which is not approved in the U. A small randomized trial of HIV medicines, published in the New England Journal of Medicine, found no overall benefit, but hints that it helped some subgroups of coronavirus patients. For drug development, getting results so soon is blindingly fast.

For doctors on the ground and patients who are struggling to breathe, it is agonizingly slow. Republish this article. Efficacy is not assessed until Phases II and III, where the drug is tested, in double-blind fashion, against a placebo control. What the heck does Trump know about medicine? He sounds like an idiot. The Pres is right on this one, we need to follow the French protocol and give very sick people a chance to live.

I agree with Thomas laValley. Are they cheerleading for the FDA? Because these are given in tablet form and there is a five day regimen hopefully wider usage on positive tested patients providing informed consent will build the case for this regimen as well as remdesivir. If a person is drowning front of you, would any of you take the time to determine if the flotation device you are about to throw is US Coast Guard approved? The hospitals should already have this information. Could be dose, or additional medical issues such as emphysema.

By Sharon Begley. By Casey Ross. By Rebecca Robbins. By Hyacinth Empinado. Support STAT: If you value our coronavirus coverage, please consider making a one-time contribution to support our journalism. About the Author. Matthew Herper Senior Writer, Medicine Matthew covers medical innovation — both its promise and its perils.

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Tags Coronavirus infectious disease public health research. Leave a Comment Cancel reply Name Please enter your name. Email Address Please enter a valid email address. Comment Please enter a comment. Continue taking the medicine regularly during your stay and for at least 8 weeks after you leave the area. If you stop using chloroquine early for any reason, talk to your doctor about other forms of malaria prevention.

To treat malaria: Chloroquine is usually given for 3 days, starting with one high dose followed by a smaller dose during the next 2 days in a row. To treat amebiasis: Chloroquine is given in a high starting dose for 2 days followed by a smaller dose for 2 to 3 weeks. You may be given other medications to help prevent further infection. Take this medicine for the full prescribed length of time for treatment of malaria. Your symptoms may improve before the infection is completely cleared.

Use protective clothing, insect repellents, and mosquito netting around your bed to further prevent mosquito bites that could cause malaria. Call your doctor as soon as possible if you have been exposed to malaria, or if you have fever or other symptoms of illness during or after a stay in an area where malaria is common. For best results, keep using the medication as directed. Talk with your doctor if you have fever, vomiting, or diarrhea during your treatment.

Could it work?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. Seek emergency medical attention or call the Poison Help line at An overdose of chloroquine can be fatal, especially in children.

Chloroquine overdose must be treated quickly. You may be told to induce vomiting right away at home, before transport to an emergency room. Ask the poison control center how to induce vomiting in the case of an overdose. Overdose symptoms may include headache, drowsiness, nausea, vomiting, vision changes, seizure convulsions , slow heart rate, weak pulse, fainting, slow breathing breathing may stop.

Avoid taking an antacid or Kaopectate kaolin-pectin within 4 hours before or after you take chloroquine. Some antacids can make it harder for your body to absorb chloroquine. If you also take an antibiotic called ampicillin, avoid taking it within 2 hours before or 2 hours after you take chloroquine. Chloroquine can make ampicillin much less effective when taken at the same time. This medication may cause blurred vision and may impair your thinking or reactions.


Be careful if you drive or do anything that requires you to be alert and able to see clearly. Get emergency medical help if you have signs of an allergic reaction hives, difficult breathing, swelling in your face or throat or a severe skin reaction fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling. Taking chloroquine long-term or at high doses may cause irreversible damage to the retina of your eye.

This is not a complete list of side effects and others may occur.


Call your doctor for medical advice about side effects. This list is not complete. Other drugs may interact with chloroquine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Every effort has been made to ensure that the information provided by Cerner Multum, Inc. Drug information contained herein may be time sensitive.

Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient.

Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects.

Anti-malarial drug is effective in treating patients